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Chang, Eugene B.
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overview The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/
One or more keywords matched the following items that are connected to Chang, Eugene B.
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Concept Allergy and Immunology
Concept Amino Acid Chloromethyl Ketones
Concept Sodium-Potassium-Exchanging ATPase
Concept Aryl Hydrocarbon Hydroxylases
Concept Food Hypersensitivity
Concept Graft vs Host Disease
Concept Hepatectomy
Concept Hexamethonium Compounds
Concept Histamine
Concept Hydrogen
Concept Hyperthermia, Induced
Concept Electrophysiology
Concept Hydroxydopamines
Concept Hypertension
Concept Hypothermia, Induced
Concept Chromatography, High Pressure Liquid
Concept Gastrointestinal Hormones
Concept Famous Persons
Concept Kidney Cortex
Concept Kidney Tubules, Proximal
Concept Health Plan Implementation
Concept Hippocampus
Concept Heart Diseases
Concept Heart Failure
Concept Hydrogen Peroxide
Concept Hydrogen-Ion Concentration
Concept Hypertonic Solutions
Concept Hypertrophy
Concept Hypoglycemic Agents
Concept Environmental Health
Concept Heptanes
Concept Hydrolases
Concept Hyperphagia
Concept Gastroenterology
Concept Gastrointestinal Hemorrhage
Concept High Mobility Group Proteins
Concept Home Care Services
Concept Hyperplasia
Concept Immunohistochemistry
Concept Receptors, Thyroid Hormone
Concept Hot Temperature
Concept Heat-Shock Proteins
Concept HeLa Cells
Concept Hemolysin Proteins
Concept Kinins
Concept Parathyroid Hormone
Concept Histocompatibility Antigens
Concept Human Experimentation
Concept Health
Concept Protein Kinases
Concept Quality of Life
Concept Ion Exchange
Concept HLA-B27 Antigen
Concept Steroid Hydroxylases
Concept Research
Concept Histones
Concept Homeostasis
Concept Humans
Concept Human Development
Concept Hydrogen Bonding
Concept Ketoconazole
Concept Kidney
Concept Sodium-Hydrogen Exchangers
Concept Mitogen-Activated Protein Kinases
Concept NF-kappa B
Concept Keratinocytes
Concept 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Concept Kidney Transplantation
Concept In Situ Hybridization
Concept Medical Oncology
Concept Receptors, Serotonin, 5-HT3
Concept Mice, Knockout
Concept HSP70 Heat-Shock Proteins
Concept Kinesiology, Applied
Concept MAP Kinase Kinase Kinases
Concept eIF-2 Kinase
Concept Hepatocytes
Concept HMGB1 Protein
Concept B7-H1 Antigen
Concept History, 21st Century
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Mitogen-Activated Protein Kinase 3
Concept Mitogen-Activated Protein Kinase 7
Concept Cyclin-Dependent Kinase Inhibitor p16
Concept Evidence-Based Medicine
Concept I-kappa B Proteins
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept Protein Kinase C
Concept HSP27 Heat-Shock Proteins
Concept Research Design
Concept Ribosomal Protein S6 Kinases, 90-kDa
Concept Specimen Handling
Concept HCT116 Cells
Concept Host-Pathogen Interactions
Concept Kruppel-Like Transcription Factors
Concept High-Throughput Screening Assays
Concept TOR Serine-Threonine Kinases
Concept High-Throughput Nucleotide Sequencing
Concept Human Umbilical Vein Endothelial Cells
Concept Wound Healing
Concept Cell Hypoxia
Concept Genome, Human
Concept HT29 Cells
Concept Mitogen-Activated Protein Kinase 1
Concept Gene Knockdown Techniques
Concept Homeodomain Proteins
Concept Home Care Services, Hospital-Based
Concept Genetic Heterogeneity
Concept HSP90 Heat-Shock Proteins
Concept Ki-67 Antigen
Concept Metagenomics
Concept Histone Deacetylase Inhibitors
Concept Sodium-Calcium Exchanger
Concept Phosphatidylinositol 3-Kinases
Concept MAP Kinase Signaling System
Concept JNK Mitogen-Activated Protein Kinases
Concept Extracellular Signal-Regulated MAP Kinases
Concept History, 20th Century
Concept AMP-Activated Protein Kinases
Concept Metabolomics
Concept Hep G2 Cells
Concept Precision Medicine
Concept Clathrin Heavy Chains
Concept Qualitative Research
Concept Peptide Hormones
Concept HSP72 Heat-Shock Proteins
Concept Diet, High-Fat
Concept Colorectal Surgery
Concept Heart Rate
Concept Hemorrhage
Concept Hyperoxaluria
Concept Kidney Calculi
Concept Kidney Medulla
Concept Kinetics
Concept Hemorheology
Concept Heat-Shock Response
Concept Computational Biology
Concept 3-Hydroxybutyric Acid
Concept Genomics
Concept Protein Kinase Inhibitors
Concept p38 Mitogen-Activated Protein Kinases
Concept MAP Kinase Kinase 5
Concept Cyclin-Dependent Kinase Inhibitor p57
Academic Article Bethanechol inhibition of chicken intestinal brush border Na/H exchange: role of protein kinase C and other calcium-dependent processes.
Academic Article Endotoxin-induced alterations in rat colonic water and electrolyte transport.
Academic Article Differential function of intestinal intraepithelial lymphocyte subsets.
Academic Article Characterization of chicken intestinal brush border membrane Na/H exchange.
Academic Article Inhibition of glycosylation decreases Na+/H+ exchange activity, blocks NHE-3 transport to the membrane, and increases NHE-3 mRNA expression in LLC-PK1 cells.
Academic Article Glycosylation of the Na+/H+ exchanger isoform NHE-3 is species specific.
Academic Article Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus.
Academic Article Tissue distribution of Na+/H+ exchanger isoforms NHE2 and NHE4 in rat intestine and kidney.
Academic Article Intestinal water and electrolyte absorption and secretion.
Academic Article Heat-shock protein 72 protects against oxidant-induced injury of barrier function of human colonic epithelial Caco2/bbe cells.
Academic Article Regulation of intestinal epithelial brush border Na(+)/H(+) exchanger isoforms, NHE2 and NHE3, in C2bbe cells.
Academic Article Glutamine protects intestinal epithelial cells: role of inducible HSP70.
Academic Article Biosynthesis and cell surface delivery of the NHE1 isoform of Na+/H+ exchanger in A6 cells.
Academic Article Effects of mesalamine on the hsp72 stress response in rat IEC-18 intestinal epithelial cells.
Academic Article An avian sodium-hydrogen exchanger.
Academic Article Inverse relationship between membrane lipid fluidity and activity of Na+/H+ exchangers, NHE1 and NHE3, in transfected fibroblasts.
Academic Article A unique Na+/H+ exchanger, analogous to NHE1, in the chicken embryonic fibroblast.
Academic Article Epithelial secretory response to inflammation.
Academic Article Phorbol ester inhibition of chicken intestinal brush-border sodium-proton exchange.
Academic Article Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa.
Academic Article Glutamine induces heat shock protein and protects against endotoxin shock in the rat.
Academic Article Oxidants potentiate Ca(2+)- and cAMP-stimulated Cl(-) secretion in intestinal epithelial T84 cells.
Academic Article Cell-specific induction of hsp72-mediated protection by glutamine against oxidant injury in IEC18 cells.
Academic Article Dexamethasone protection of rat intestinal epithelial cells against oxidant injury is mediated by induction of heat shock protein 72.
Academic Article Expression of multiple Na+/H+ exchanger isoforms in rat parotid acinar and ductal cells.
Academic Article Ca-mediated stimulation of Cl secretion by reactive oxygen metabolites in human colonic T84 cells.
Academic Article Regional alterations in intestinal sucrase expression in streptozocin-treated chronically diabetic rats.
Academic Article SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells.
Academic Article Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells.
Academic Article Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function.
Academic Article Surgical stress shifts the intestinal Escherichia coli population to that of a more adherent phenotype: role in barrier regulation.
Academic Article Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection.
Academic Article Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress.
Academic Article Cystic fibrosis transmembrane regulator mRNA expression relative to ion-nutrient transport in spontaneously differentiating human intestinal CaCo-2 epithelial cells.
Academic Article Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function.
Academic Article Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic.
Academic Article Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction.
Academic Article Heat shock protein 72 binds and protects dihydrofolate reductase against oxidative injury.
Academic Article T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase.
Academic Article IFN-gamma downregulates expression of Na(+)/H(+) exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells.
Academic Article High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa.
Academic Article Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity.
Academic Article Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition.
Academic Article Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells.
Academic Article Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells.
Academic Article Recognition of host immune activation by Pseudomonas aeruginosa.
Academic Article Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72.
Academic Article AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins.
Academic Article Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells.
Academic Article Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa.
Academic Article This month in gastroenterology.
Academic Article Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption.
Academic Article Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa.
Academic Article Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine.
Academic Article Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure.
Academic Article Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium.
Academic Article Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System.
Academic Article fMLP induces Hsp27 expression, attenuates NF-kappaB activation, and confers intestinal epithelial cell protection.
Academic Article Posttranslational processing of ras proteins.
Academic Article Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.
Academic Article Escherichia coli LPS induces heat shock protein 25 in intestinal epithelial cells through MAP kinase activation.
Academic Article Therapy Insight: gastrointestinal complications of diabetes--pathophysiology and management.
Academic Article The effect of antireflux surgery on esophageal carcinogenesis in patients with barrett esophagus: a systematic review.
Academic Article Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na+ pump activity.
Academic Article Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation.
Academic Article hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells.
Academic Article The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter.
Academic Article Acid secretion by parietal cells: relative roles for [Ca2+]i and protein kinase C.
Academic Article Utilization of the delay phenomenon improves blood flow and reduces collagen deposition in esophagogastric anastomoses.
Academic Article The pharmacological modification of secretory responses.
Academic Article Determinants of regional sucrase-isomaltase expression in adult rat small intestine.
Academic Article Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa. Selective inhibition by loperamide.
Academic Article Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.
Academic Article Role and regulation of intestinal epithelial heat shock proteins in health and disease.
Academic Article Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Academic Article Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells.
Academic Article Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa.
Academic Article Heat induction of heat shock protein 25 requires cellular glutamine in intestinal epithelial cells.
Academic Article Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis.
Academic Article Cytokine regulation of OCTN2 expression and activity in small and large intestine.
Academic Article Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin.
Academic Article Phorbol ester-stimulated secretion in chicken ileum: role of arachidonic acid metabolism.
Academic Article Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon.
Academic Article Intestinal electrolyte transport and diarrheal disease (1).
Academic Article Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.
Academic Article 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis.
Academic Article The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer.
Academic Article Standard colonic lavage alters the natural state of mucosal-associated microbiota in the human colon.
Academic Article Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1.
Academic Article Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer.
Academic Article Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma.
Academic Article Increased Likelihood of Bacterial Pathogens in the Coronal Sulcus and Urethra of Uncircumcised Men in a Diverse Group of HIV Infected and Uninfected Patients in India.
Academic Article Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha.
Academic Article Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response.
Academic Article miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes.
Academic Article Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells.
Academic Article Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function.
Academic Article Preserved Na(+)/H(+) exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitis.
Academic Article American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.
Academic Article Glucose enhancement of transcellular calcium transport in the intestine.
Academic Article The colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhances adaptive immune responses to a bacterial antigen.
Academic Article Lymphotoxin regulates commensal responses to enable diet-induced obesity.
Academic Article Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins.
Academic Article A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity.
Academic Article Effect of high osmolality on Na+/H+ exchange in renal proximal tubule cells.
Academic Article Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.
Academic Article Na+/H+ exchangers, NHE-1 and NHE-3, of rat intestine. Expression and localization.
Academic Article Effect of glucose on calcium transport in rat duodenum.
Academic Article Phorbol ester inhibition of Na-H exchange in rabbit proximal colon.
Academic Article Salmonella bacterial adherence and penetration of mucosal cells: inducing role of the epithelium.
Academic Article Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection.
Academic Article NHE-1 isoform of the Na+/H+ antiport is expressed in the rat and rabbit esophagus.
Academic Article Pancreatic cholera: is the diarrhea due to VIP?
Academic Article An antiabsorptive basis for precipitated withdrawal diarrhea in morphine-dependent rats.
Academic Article Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine.
Academic Article Intestinal adaptation to diabetes. Altered Na-dependent nutrient absorption in streptozocin-treated chronically diabetic rats.
Academic Article Calcium-mediated cyclic AMP inhibition of Na-H exchange in small intestine.
Academic Article Expression and phosphorylation of NHE1 in wild-type and transformed human and rodent fibroblasts.
Academic Article Localization of the Na+/H+ exchanger isoform NHE-3 in rabbit and canine kidney.
Academic Article Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.
Academic Article The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away.
Academic Article Do heat shock proteins play any role in gut inflammation?
Academic Article Differential regulation of Na+/H+ exchange and H(+)-ATPase by pH and HCO3- in kidney proximal tubules.
Academic Article PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.
Academic Article Phorbol ester stimulation of active anion secretion in intestine.
Academic Article Treatment of diabetic diarrhea with clonidine.
Academic Article Induction of heat shock protein 70 protects intestinal epithelial IEC-18 cells from oxidant and thermal injury.
Academic Article Glucocorticoids regulate Na+/H+ exchange expression and activity in region- and tissue-specific manner.
Academic Article Small intestine hexose transport in experimental diabetes. Increased transporter mRNA and protein expression in enterocytes.
Academic Article Aldosterone stimulates intestinal Na+ absorption in rats by increasing NHE3 expression of the proximal colon.
Academic Article Regulation of apical membrane Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe.
Academic Article The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis.
Academic Article Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells.
Academic Article Anti-apoptotic effects of L-glutamine-mediated transcriptional modulation of the heat shock protein 72 during heat shock.
Academic Article Inhibition of Na/H exchange in avian intestine by atrial natriuretic factor.
Academic Article Protein kinase C unleashed.
Academic Article Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells.
Academic Article Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3.
Academic Article Intestinal electrolyte transport and diarrheal disease (2)
Academic Article Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium.
Academic Article Effects of serotonin on Na+-H+ exchange and intracellular calcium in isolated chicken enterocytes.
Academic Article Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells.
Academic Article Alpha-vitamin E derivative, RRR-alpha-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells.
Academic Article Requirements for ion and solute transport, and pH regulation during enamel maturation.
Academic Article SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes.
Academic Article Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases.
Academic Article Targeting vaccinia to solid tumors with local hyperthermia.
Academic Article Serum uric Acid as a predictor for the development of nonalcoholic Fatty liver disease in apparently healthy subjects: a 5-year retrospective cohort study.
Academic Article p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
Academic Article Parathyroid hormone suppresses insulin signaling in adipocytes.
Academic Article Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells.
Academic Article Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis.
Academic Article Fresh perspectives in chronic constipation and other functional bowel disorders.
Academic Article 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes.
Academic Article Dietary intervention with vitamin D, calcium, and whey protein reduced fat mass and increased lean mass in rats.
Academic Article Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.
Academic Article MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation.
Academic Article Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.
Academic Article A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Academic Article Carrageenan-induced colonic inflammation is reduced in Bcl10 null mice and increased in IL-10-deficient mice.
Academic Article De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis.
Academic Article Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
Academic Article TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-?B suppression.
Academic Article Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.
Academic Article Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants.
Academic Article Commensal bacteria protect against food allergen sensitization.
Academic Article Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.
Academic Article Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection.
Academic Article Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.
Academic Article Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis.
Academic Article The microbial basis of inflammatory bowel diseases.
Academic Article Comparison of brush and biopsy sampling methods of the ileal pouch for assessment of mucosa-associated microbiota of human subjects.
Academic Article Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
Academic Article Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?
Academic Article Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa.
Academic Article Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected].
Academic Article Exploring gut microbes in human health and disease: Pushing the envelope.
Academic Article Michael Field, MD (1933-2014).
Academic Article The role of diet in triggering human inflammatory disorders in the modern age.
Academic Article Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue.
Academic Article Nutrition, microbiomes, and intestinal inflammation.
Academic Article Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases.
Academic Article The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013.
Award or Honor Receipt National Diabetes and Digestive and Kidney Disease Advisory Council
Award or Honor Receipt NIH Merit Award
Academic Article Sirt1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation.
Academic Article Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model.
Academic Article IBD and the gut microbiota--from bench to personalized medicine.
Academic Article Intracellular HMGB1: defender of client proteins and cell fate.
Academic Article Towards anatomic scale agent-based modeling with a massively parallel spatially explicit general-purpose model of enteric tissue (SEGMEnT_HPC).
Academic Article Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.
Academic Article N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model.
Academic Article Neuroprotective interventions: is it too late?
Academic Article Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model.
Academic Article New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis.
Academic Article Lloyd F. Mayer, MD: a remembrance.
Academic Article Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis.
Academic Article Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Academic Article Adiponectin deletion impairs insulin signaling in insulin-sensitive but not insulin-resistant 3T3-L1 adipocytes.
Academic Article Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases.
Academic Article Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats.
Academic Article Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1a and transforming growth factor-ß1 expression.
Academic Article Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury.
Academic Article Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice.
Academic Article Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.
Academic Article Restoration of adiponectin expression via the ERK pathway in TNFa-treated 3T3-L1 adipocytes.
Academic Article Novel role of kallistatin in vascular repair by promoting mobility, viability, and function of endothelial progenitor cells.
Academic Article Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.
Academic Article Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids.
Academic Article Dead or alive: Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome.
Academic Article Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Academic Article Ezetimibe stimulates intestinal glucagon-like peptide 1 secretion via the MEK/ERK pathway rather than dipeptidyl peptidase 4 inhibition.
Academic Article Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor.
Academic Article Common problems in critically ill obstetric patients, with an emphasis on pharmacotherapy.
Academic Article Transplanting a Microbial Organ: the Good, the Bad, and the Unknown.
Academic Article Androgen receptor (AR) in cardiovascular diseases.
Academic Article A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice.
Academic Article New insights into the pathogenesis of cystic fibrosis sinusitis.
Academic Article Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.
Academic Article Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Academic Article Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.
Academic Article Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.
Academic Article Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.
Academic Article Precision Genomic Medicine in Cystic Fibrosis.
Academic Article Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats.
Academic Article Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells.
Academic Article Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress.
Academic Article Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota.
Academic Article The gut microbiota and inflammatory bowel diseases.
Academic Article Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.
Academic Article The Gut Microbiota: The Gateway to Improved Metabolism.
Academic Article Patient-Specific Bacteroides Genome Variants in Pouchitis.
Academic Article Western diets, gut dysbiosis, and metabolic diseases: Are they linked?
Academic Article Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases.
Academic Article Evolutionary and ecological forces that shape the bacterial communities of the human gut.
Academic Article Kinase-SUMO networks in diabetes-mediated cardiovascular disease.
Academic Article Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis.
Academic Article Krüppel-like factors in endothelial cell biology.
Academic Article Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.
Academic Article Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes.
Academic Article Microbial metabolites in health and disease: Navigating the unknown in search of function.
Academic Article A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade.
Academic Article Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway.
Academic Article Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.
Academic Article Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected].
Academic Article Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice.
Academic Article Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Academic Article Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption.
Academic Article Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal.
Academic Article Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2.
Academic Article Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats.
Academic Article Factors affecting hospital length of stay following pelvic exenteration surgery.
Academic Article Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.
Academic Article The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease.
Academic Article Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.
Academic Article The Human Microbiome and Obesity: Moving beyond Associations.
Academic Article Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts.
Academic Article Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis.
Academic Article Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice.
Academic Article Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome.
Academic Article Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions.
Academic Article Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Academic Article Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes.
Academic Article Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.
Academic Article Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis.
Academic Article Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats.
Academic Article Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy.
Academic Article Challenges in IBD Research: Preclinical Human IBD Mechanisms.
Academic Article Responsible stewardship for communicating microbiome research to the press and public.
Academic Article Development, implementation, and effects of a cancer center's exercise-oncology program.
Academic Article Regional Diversity of the Gastrointestinal Microbiome.
Academic Article Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury.
Academic Article Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism.
Academic Article Aerobic capacity attainment and reasons for cardiopulmonary exercise test termination in people with cancer: a descriptive, retrospective analysis from a single laboratory.
Academic Article TGR5 signaling mitigates parenteral nutrition-associated liver disease.
Academic Article Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty.
Academic Article Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury.
Academic Article IBD Microbial Metabolome: The Good, Bad, and Unknown.
Academic Article Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells.
Academic Article Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial.
Academic Article Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes.
Academic Article Authors' Response: The three faces of Takotsubo cardiomyopathy in a single patient.
Academic Article Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.
Academic Article Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine Model.
Academic Article CaRE @ Home: Pilot Study of an Online Multidimensional Cancer Rehabilitation and Exercise Program for Cancer Survivors.
Academic Article "This is my home-based exercise": exploring environmental influences on home-based exercise participation in oncology.
Academic Article Development and Validation of a Risk Model for Breast Cancer-Related Lymphedema.
Academic Article Navigating the Human Gut Microbiome: Pathway to Success from Lessons Learned.
Academic Article Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.
Academic Article The Gut Microbiome: Reaching the Promise Through Discovery- Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine.
Academic Article Endoscopic Phenotype of the J Pouch in Patients With Inflammatory Bowel Disease: A New Classification for Pouch Outcomes.
Academic Article The microbiome: Composition and locations.
Academic Article Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism.
Academic Article Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice.
Academic Article Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier.
Academic Article High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota.
Academic Article The Gut Microbiome and Inflammatory Bowel Diseases.
Academic Article Chrysanthemum morifolium Flower Extract Ameliorates Obesity-Induced Inflammation and Increases the Muscle Mitochondria Content and AMPK/SIRT1 Activities in Obese Rats.
Academic Article A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2.
Academic Article KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression.
Academic Article Outcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch-Anal Anastomosis in Pediatric Ulcerative Colitis.
Academic Article Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis.
Academic Article The regulatory role of N6 -methyladenosine modification in the interaction between host and microbes.
Academic Article High-fat diet disrupts REG3? and gut microbial rhythms promoting metabolic dysfunction.
Academic Article High-Fat Diet Alters the Retinal Pigment Epithelium and Choroidal Transcriptome in the Absence of Gut Microbiota.
Academic Article Effects of Vitamin D Supplementation on Adipose Tissue Inflammation and NF-?B/AMPK Activation in Obese Mice Fed a High-Fat Diet.
Concept NF-KappaB Inhibitor alpha
Concept Proof of Concept Study
Concept Sodium-Hydrogen Exchanger 3
Concept Myristoylated Alanine-Rich C Kinase Substrate
Concept Heat Shock Transcription Factors
Concept Gene Ontology
Concept Vitamin D3 24-Hydroxylase
Academic Article A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut.
Academic Article Sel1-like proteins and peptides are the major Oxalobacter formigenes-derived factors stimulating oxalate transport by human intestinal epithelial cells.
Academic Article Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient.
Academic Article Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity.
Academic Article Novel role of surfactant protein A in bacterial sinusitis.
Academic Article Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization.
Academic Article Western Diet-induced Transcriptional Changes in Anastomotic Tissue Is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery.
Academic Article Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.
Academic Article The Host-specific Microbiota is Required for Diet-Specific Metabolic Homeostasis.
Academic Article Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient.
Academic Article Microbially catalyzed conjugation of GABA and tyramine to bile acids.
Academic Article A novel conjugative transposon carrying an autonomously amplified plasmid.
Academic Article Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
Academic Article A cryptic plasmid is among the most numerous genetic elements in the human gut.
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